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. 2016 May;95(18):e3373.
doi: 10.1097/MD.0000000000003373.

The Effectiveness of Transforaminal Versus Caudal Routes for Epidural Steroid Injections in Managing Lumbosacral Radicular Pain: A Systematic Review and Meta-Analysis

Jun Liu  1 , Hengxing Zhou, Lu Lu, Xueying Li, Jun Jia, Zhongju Shi, Xue Yao, Qiuli Wu, Shiqing Feng
Affiliations

The Effectiveness of Transforaminal Versus Caudal Routes for Epidural Steroid Injections in Managing Lumbosacral Radicular Pain: A Systematic Review and Meta-Analysis

Jun Liu et al. Medicine (Baltimore). 2016 May.

Abstract

Epidural steroid injection (ESI) is one of the most commonly used treatments for radiculopathy. Previous studies have described the effectiveness of ESI in the management of radiculopathy. However, controversy exists regarding the route that is most beneficial and effective with respect to the administration of epidural steroids, as both transforaminal (TF) and caudal (C) routes are commonly used.This analysis reviewed studies comparing the effectiveness of TF-ESIs with that of C-ESIs in the treatment of radiculopathy as a means of providing pain relief and improving functionality. This meta-analysis was performed to guide clinical decision-making.The study was a systematic review of comparative studies.A systematic literature search was performed using the PubMed, EMBASE, and Cochrane Library databases for trials written in English. The randomized trials and observational studies that met our inclusion criteria were subsequently included. Two reviewers, respectively, extracted data and estimated the risk of bias. All statistical analyses were performed using Review Manager 5.3.Six prospective and 2 retrospective studies involving 664 patients were included. Statistical analysis was performed utilizing only the 6 prospective studies. Although slight pain and functional improvements were noted in the TF-ESI groups compared with the C-ESI groups, these improvements were neither clinically nor statistically significant.The limitations of this meta-analysis resulted primarily from the weaknesses of the comparative studies and the relative paucity of patients included in each study.Both the TF and C approaches are effective in reducing pain and improving functional scores, and they demonstrated similar efficacies in the management of lumbosacral radicular pain.

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Conflict of interest statement

Conflicts of interest: None of the authors of the manuscript received any remuneration. Further, the authors have not received any reimbursement or honorarium in any other manner.

The authors report no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Comparison of TF versus C with respect to pain level after epidural steroid injections at 2 weeks (A), 3 months (B), 6 months (C), and 12 months (D). C = caudal, TF = transforaminal.
FIGURE 2
FIGURE 2
Comparison of TF versus C with respect to functional level after epidural steroid injections at 2 weeks (A), 3 months (B), 6 months (C), and 12 months (D). C = caudal, TF = transforaminal.
FIGURE 3
FIGURE 3
Flow diagram of the search and selection criteria for inclusion in this meta-analysis.
FIGURE 4
FIGURE 4
Risk of bias assessment of each included study. A, Risk of bias graph. B, Risk of bias summary.
See this image and copyright information in PMC

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