The Diagnostic Value of Gastrin-17 Detection in Atrophic Gastritis: A Meta-Analysis

Abstract

A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG).An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. To assess the diagnostic value of G-17, the following statistics were estimated and described: sensitivity, specificity, diagnostic odds ratios (DOR), summary receiver operating characteristic curves, area under the curve (AUC), and 95% confidence intervals (CIs).Thirteen studies that met the inclusion criteria were included in this meta-analysis, comprising 894 patients and 1950 controls. The pooled sensitivity and specificity of these studies were 0.48 (95% CI: 0.45-0.51) and 0.79 (95% CI: 0.77-0.81), respectively. The DOR was 5.93 (95% CI: 2.93-11.99), and the AUC was 0.82.G-17 may have potential diagnostic value because it has good specificity and a moderate DOR and AUC for CAG. However, more studies are needed to improve the sensitivity of this diagnostic tool in the future.

FIGURE 1

Forest plots of DOR of G-17 detection in CAG. The solid circles and horizontal lines correspond to the study-specific OR and 95% CIs, and the size of the circle reflects the study-specific weight. The length of diamond represents the combined 95% CI and the center represents the combined OR. CAG = chronic atrophic gastritis, CI = confidence interval, DOR = diagnostic odds ratios, G-17 = gastrin-17, OR = odds ratio.

FIGURE 2

SROC curves for G-17 detection in CAG. The solid circles represent the studies included in the meta-analysis, and the size of the circle indicates the number of samples in each study. AUC = area under the curve, CAG = chronic atrophic gastritis, G-17 = gastrin-17, SROC = summary receiver operating characteristic.

FIGURE 3

Forest plots of sensitivity of G-17 detection in CAG. The solid circles and horizontal lines correspond to the study-specific OR and 95% CIs, and the size of the circle reflects the study-specific weight. The length of diamond represents the combined 95% CI and the center represents the combined OR. CAG = chronic atrophic gastritis, CI = confidence interval, G-17 = gastrin-17, OR = odds ratio.

FIGURE 4

Forest plots of specificity of G-17 detection in CAG. The solid circles and horizontal lines correspond to the study-specific OR and 95% CIs, and the size of the circle reflects the study-specific weight. The length of diamond represents the combined 95% CI and the center represents the combined OR. CAG = chronic atrophic gastritis, CI = confidence interval, G-17 = gastrin-17, OR = odds ratio.

FIGURE 5

Forest plots of PLR of G-17 detection in CAG. The solid circles and horizontal lines correspond to the study-specific OR and 95% CIs, and the size of the circle reflects the study-specific weight. The length of diamond represents the combined 95% CI and the centre represents the combined OR. CAG = chronic atrophic gastritis, CI = confidence interval, G-17 = gastrin-17, OR = odds ratio, PLR = positive likelihood ratio.

FIGURE 6

Forest plots of NLR of G-17 detection in CAG. The solid circles and horizontal lines correspond to the study-specific OR and 95% CIs, and the size of the circle reflects the study-specific weight. The length of diamond represents the combined 95% CI and the centre represents the combined OR.CAG = chronic atrophic gastritis, CI = confidence interval, G-17 = gastrin-17, NLR = negative likelihood ratio, OR = odds ratio,.

FIGURE 7

Assessment of potential publication bias in the detection of chronic atrophic gastritis (CAG). The solid circles represent individual studies. Horizontal lines correspond to the regression line.