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Review
. 2016:1438:123-35.
doi: 10.1007/978-1-4939-3661-8_8.

Germ-Free Mice Model for Studying Host-Microbial Interactions

Yogesh Bhattarai  1 , Purna C Kashyap  2
Affiliations
Review

Germ-Free Mice Model for Studying Host-Microbial Interactions

Yogesh Bhattarai et al. Methods Mol Biol. 2016.

Abstract

Germ-free (GF) mice are a relevant model system to study host-microbial interactions in health and disease. In this chapter, we underscore the importance of using GF mice model to study host-microbial interactions in obesity, immune development and gastrointestinal physiology by reviewing current literature. Furthermore, we also provide a brief protocol on how to setup a gnotobiotic facility in order to properly maintain and assess GF status in mice colonies.

Keywords: Germ-free; Gnotobiotic; Gut microbiome.

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