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Case Reports
. 2016;55(9):1143-7.
doi: 10.2169/internalmedicine.55.4418. Epub 2016 May 1.

Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist

Hiroyo Ninomiya  1 , Ayumu Hirata, Junji Kozawa, Shinsuke Nakata, Takekazu Kimura, Tetsuhiro Kitamura, Tetsuyuki Yasuda, Michio Otsuki, Akihisa Imagawa, Hideaki Kaneto, Tohru Funahashi, Iichiro Shimomura
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Free article
Case Reports

Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist

Hiroyo Ninomiya et al. Intern Med. 2016.
Free article

Abstract

The 3243 A>G mutation in mitochondrial DNA is the most common cause of monogenic diabetes mellitus in Japan. A 45-year-old woman with mitochondrial diabetes and significant insulin resistance presented with hypoadiponectinemia despite a normal amount of visceral fat. Three months of treatment with pioglitazone (PIO) improved her blood glucose profile and response to the 75-g oral glucose tolerance test. These changes were accompanied by the amelioration of her insulin resistance and the impairment of early-phase insulin secretion. Her serum adiponectin levels increased to the normal range. In this case of mitochondrial diabetes, PIO was effective for glycemic control.

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Comment in

  • Diabetes due to Mitochondrial Adipopathy.
    Ninomiya H, Hirata A, Kozawa J, Imagawa A, Shimomura I. Ninomiya H, et al. Intern Med. 2017;56(6):745. doi: 10.2169/internalmedicine.56.7950. Epub 2017 Mar 17. Intern Med. 2017. PMID: 28321084 Free PMC article. No abstract available.
  • Diabetes due to Mitochondrial Adipopathy.
    Finsterer J, Frank M. Finsterer J, et al. Intern Med. 2017;56(6):747. doi: 10.2169/internalmedicine.56.7750. Epub 2017 Mar 17. Intern Med. 2017. PMID: 28321085 Free PMC article. No abstract available.

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