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. 2016 Dec;15(4):455-466.
doi: 10.1177/1534735416635741. Epub 2016 May 4.

Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study

Maja S Sommer  1 , Karen Trier  2 , Jette Vibe-Petersen  2 , Malene Missel  3 , Merete Christensen  3 , Klaus R Larsen  4 , Seppo W Langer  3 , Carsten Hendriksen  3 , Paul Frost Clementsen  3   5 , Jesper H Pedersen  3 , Henning Langberg  3
Affiliations

Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study

Maja S Sommer et al. Integr Cancer Ther. 2016 Dec.

Abstract

Introduction Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery. Conclusion The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.

Keywords: NSCLC; exercise; lung cancer; perioperative intervention; rehabilitation.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Timeline for the PROLUCA feasibility study.
Figure 2.
Figure 2.
Rehabilitation services available between diagnosis and follow-up at the rehabilitation center.
Figure 3.
Figure 3.
Flow PROLUCA feasibility study.
See this image and copyright information in PMC

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