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Comment
. 2016 May 5;127(18):2168-70.
doi: 10.1182/blood-2016-02-699058.

NEDD8 and HDACs: promising cotargets in AML

Kapil N Bhalla  1 , Warren Fiskus  1
Affiliations
Comment

NEDD8 and HDACs: promising cotargets in AML

Kapil N Bhalla et al. Blood. .

Abstract

In this issue of Blood, Zhou et al have identified synergistic in vitro and in vivo anti–acute myeloid leukemia (AML) activity of the lysine neddylation inhibitor pevonedistat and pan–histone deacetylase (HDAC) inhibitor (pan-HDACI) belinostat and examine the mechanisms responsible for this synergistic activity.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Mechanistic interactions creating synergy between pevonedistat and belinostat against AML blast progenitor cells (BPCs).
See this image and copyright information in PMC

Comment on

References

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