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. 2016 May;57(5):511-3.

Clinical presentation and management of suspected ribavirin toxicosis in a dog

Kimberly Bridges  1 , Nicole Beckel  1 , Claire Sharp  1 , Laura Stern  1
Affiliations

Clinical presentation and management of suspected ribavirin toxicosis in a dog

Kimberly Bridges et al. Can Vet J. 2016 May.

Abstract
in English, French

A 5-month-old pit bull terrier was presented for evaluation of progressive lethargy, vomiting, diarrhea, and anorexia 45 hours after ingestion of 625 mg/kg body weight (BW) (9000 mg) of the antiviral medication, ribavirin. Abnormalities that were detected included dehydration, tachycardia, elevated liver enzymes, and prolonged prothrombin time. The dog was discharged after 5 days of aggressive supportive care consisting of intravenous fluids, antiemetics, gastroprotectants, hepatoprotectants, dextrose supplementation, and vitamin B/K1 supplementation.

Présentation clinique et gestion d’une toxicose à la ribavirine suspectée chez un chien. Un chien Pit bull Terrier âgé de 5 mois a été présenté pour l’évaluation d’un abattement progressif, de vomissements, de diarrhée et d’une anorexie 45 heures après l’ingestion de 625 mg/kg poids corporel (PC) du médicament antiviral ribavirine. Les anomalies détectées incluaient la déshydratation, la tachycardie, des enzymes hépatiques élevés et un temps de prothrombine prolongé. Le chien a reçu son congé après 5 jours de soins de soutien agressifs composés de liquides intraveineux, d’antiémétiques, de gastroprotectants, d’hépatoprotectants, de supplémentation en dextrose et de supplémentation en vitamine B/K1.(Traduit par Isabelle Vallières).

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