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Review
. 2016;89(2):203-11.
doi: 10.15386/cjmed-570. Epub 2016 Apr 15.

Circulating tumor cells in germ cell tumors: are those biomarkers of real prognostic value? A review

Cristina Ligia Cebotaru  1 , Elena Diana Olteanu  1 , Nicoleta Zenovia Antone  2 , Rares Buiga  2 , Viorica Nagy  1
Affiliations
Review

Circulating tumor cells in germ cell tumors: are those biomarkers of real prognostic value? A review

Cristina Ligia Cebotaru et al. Clujul Med. 2016.

Abstract

Analysis of circulating tumor cells from patients with different types of cancer is nowadays a fascinating new tool of research and their number is proven to be useful as a prognostic factor in metastatic breast, colon and prostate cancer patients. Studies are going beyond enumeration, exploring the circulating tumor cells to better understand the mechanisms of tumorigenesis, invasion and metastasis and their value for characterization, prognosis and tailoring of treatment. Few studies investigated the prognostic significance of circulating tumor cells in germ cell tumors. In this review, we examine the possible significance of the detection of circulating tumor cells in this setting.

Keywords: biomarkers; circulating tumor cells; germ cell tumors.

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