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Review
. 2016 May 5:13:10.
doi: 10.1186/s12014-016-9112-2. eCollection 2016.

Clinical proteomics of enervated neurons

Mohor Biplab Sengupta #  1 , Arunabha Chakrabarti #  1 , Suparna Saha  1 , Debashis Mukhopadhyay  1
Affiliations
Review

Clinical proteomics of enervated neurons

Mohor Biplab Sengupta et al. Clin Proteomics. .

Abstract

The dynamic field of neurosciences entails ever increasing search for molecular mechanisms of disease states, especially in the domain of neurodegenerative disorders. The previous century heralded the techniques in proteomics when indexing of the human proteomes relating to various disease conditions became important. Early stage research in certain diseases or pathological conditions requires a more holistic approach of first discovering the proteins of interest for the condition. Despite its limitations, proteomics is one of the most powerful techniques available to us today to dissect the molecular scenario in a particular disease situation. In this review we will discuss about the current clinical research in neurodegenerative disorders that employ proteomics techniques. We will specifically focus on our understanding of Alzheimer's disease, traumatic spinal cord injury and neuromyelitis optica. Discussions will include ongoing worldwide research in these areas, research in India and specifically our laboratory in these domains of neurodegenerative conditions.

Keywords: Alzheimer’s disease; Neurodegeneration; Neuromyelitis optica; Proteomics; Spinal cord injury.

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Figures

Fig. 1
Fig. 1
A representative diagram of the paradigm adopted by our laboratory in neurodegeneration research. Starting with Alzheimer’s disease, in proteomics domain, we found out the interacting partners of AICD in CSF and AICD-transfected human and mouse cell lines. Twenty novel AICD interactors were found in mouse neuroblastoma cells. The study was further followed up in human CSF, where differentially expressed AICD interactors were found out. Finally, differential expression of AICD interactors were studied in human and mouse neuroblastoma. Moving forward to spinal cord injury, we looked at differentially abundant proteins in the CSF of SCI patients with different severity grades of injury. An interaction network was created using the proteins found in the CSF of AIS grade A injury and modularization of the same revealed a number of perturbed pathways. Finding putative disease markers for the rather evasive successful marker hunting in neuromyelitis optica remains a future perspective
See this image and copyright information in PMC

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