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Case Reports
. 2016 Apr;22(1):50-3.
doi: 10.6118/jmm.2016.22.1.50. Epub 2016 Apr 26.

Epithelioid Trophoblastic Tumor in a Postmenopausal Woman: A Case Report

Jung-Woo Park  1 , Jong Woon Bae  1
Affiliations
Case Reports

Epithelioid Trophoblastic Tumor in a Postmenopausal Woman: A Case Report

Jung-Woo Park et al. J Menopausal Med. 2016 Apr.

Abstract

Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm composed of intermediate trophoblasts. Most cases of ETT are reported in women of reproductive age following a prior gestation within 2 weeks to 30 years. ETT is extremely rare in postmenopausal women. It is commonly misdiagnosed as a poorly differentiated carcinoma or another type of gestational trophoblastic tumor. We report a case of ETT in a 56-year-old woman that developed 23 years after the patient's last pregnancy.

Keywords: Epithelioid trophoblastic tumor; Postmenopause; Uterus.

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Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Endometrial biopsy specimen show nodular proliferation of epithelioid trophoblasts (H&E, ×10).
Fig. 2
Fig. 2. A total hysterectomy specimen showed a slightly enlarged uterus.
Fig. 3
Fig. 3. The tumor showed cell necrosis with hyaline-like material, resembling squamous cell carcinoma with stromal invasion (arrow, H&E ×400).
Fig. 4
Fig. 4. Immunohistochemistry showed a diffuse positive staining for placental alkaline phosphatase (PLAP) (A, ×100), P63 (B, ×100), and highly positive for Ki67 (C, ×100).
See this image and copyright information in PMC

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