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Comment
. 2016 May 5;18(5):564-6.
doi: 10.1016/j.stem.2016.04.010.

You Are What You Eat: Linking High-Fat Diet to Stem Cell Dysfunction and Tumorigenesis

Samantha Haller  1 , Heinrich Jasper  2
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You Are What You Eat: Linking High-Fat Diet to Stem Cell Dysfunction and Tumorigenesis

Samantha Haller et al. Cell Stem Cell. .
Free article

Abstract

A high-fat diet is linked to elevated cancer risk, yet this link remains poorly understood. New studies in mice are now beginning to obtain mechanistic insight into how high-fat diets perturb stem cell function and cause cancers.

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  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
    Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH. Beyaz S, et al. Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173. Nature. 2016. PMID: 26935695 Free PMC article.

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