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. 2016 Oct;21(5):909-919.
doi: 10.1007/s10147-016-0986-9. Epub 2016 May 6.

Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma

Noriyuki Hirahara  1 , Takeshi Matsubara  2 , Daisuke Kawahara  2 , Yoko Mizota  2 , Shuichi Ishibashi  2 , Yoshitsugu Tajima  2
Affiliations

Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma

Noriyuki Hirahara et al. Int J Clin Oncol. 2016 Oct.

Abstract

Background: It is now widely recognized that outcomes in cancer patients are not determined by their tumor characteristics alone. In this study, we retrospectively analyzed the clinical data of esophageal cancer patients to evaluate the impact of red blood cell distribution width (RDW), platelet distribution width (PDW), and mean platelet volume (MPV) on cancer-specific survival (CSS).

Study design: We retrospectively reviewed a database of 144 consecutive patients who underwent curative esophagectomy for esophageal squamous cell carcinoma at our institute between 2006 and 2014.

Result: In multivariate analysis, pathological stage (pStage) (p = 0.0002) and a high RDW (p = 0.0300) were found to be independently associated with poor survival. Patients with a high RDW had a significantly poorer prognosis in terms of CSS than those with a low RDW (p = 0.004). Among non-elderly patients, multivariate analysis demonstrated that pStage (p = 0.0120), and a high RDW (p = 0.0092) were independent risk factors for a worse prognosis. In addition, non-elderly patients with a high RDW had a significantly poorer prognosis in terms of CSS than those with a low RDW (p = 0.0003). On the other hand, univariate analysis demonstrated that pStage (p = 0.0008) was the only significant risk factor for a poor prognosis in elderly patients.

Conclusions: We confirmed that a high RDW was significantly associated with the CSS of esophageal cancer patients after curative esophagectomy. Furthermore, in non-elderly patients, a high RDW was a significant and independent predictor of poor survival.

Keywords: Esophageal cancer; Prognostic predictor; Red cell distribution width (RDW).

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Postoperative cancer-specific survival based on RDW in 144 patients with esophageal cancer
Fig. 2
Fig. 2
Postoperative cancer-specific survival based on RDW in 97 non-elderly patients with esophageal cancer
Fig. 3
Fig. 3
Postoperative cancer-specific survival based on RDW in 47 elderly patients with esophageal cancer
See this image and copyright information in PMC

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