Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;21(5):909-919.
doi: 10.1007/s10147-016-0986-9. Epub 2016 May 6.

Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma

Noriyuki Hirahara  1 , Takeshi Matsubara  2 , Daisuke Kawahara  2 , Yoko Mizota  2 , Shuichi Ishibashi  2 , Yoshitsugu Tajima  2
Affiliations

Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma

Noriyuki Hirahara et al. Int J Clin Oncol. 2016 Oct.

Abstract

Background: It is now widely recognized that outcomes in cancer patients are not determined by their tumor characteristics alone. In this study, we retrospectively analyzed the clinical data of esophageal cancer patients to evaluate the impact of red blood cell distribution width (RDW), platelet distribution width (PDW), and mean platelet volume (MPV) on cancer-specific survival (CSS).

Study design: We retrospectively reviewed a database of 144 consecutive patients who underwent curative esophagectomy for esophageal squamous cell carcinoma at our institute between 2006 and 2014.

Result: In multivariate analysis, pathological stage (pStage) (p = 0.0002) and a high RDW (p = 0.0300) were found to be independently associated with poor survival. Patients with a high RDW had a significantly poorer prognosis in terms of CSS than those with a low RDW (p = 0.004). Among non-elderly patients, multivariate analysis demonstrated that pStage (p = 0.0120), and a high RDW (p = 0.0092) were independent risk factors for a worse prognosis. In addition, non-elderly patients with a high RDW had a significantly poorer prognosis in terms of CSS than those with a low RDW (p = 0.0003). On the other hand, univariate analysis demonstrated that pStage (p = 0.0008) was the only significant risk factor for a poor prognosis in elderly patients.

Conclusions: We confirmed that a high RDW was significantly associated with the CSS of esophageal cancer patients after curative esophagectomy. Furthermore, in non-elderly patients, a high RDW was a significant and independent predictor of poor survival.

Keywords: Esophageal cancer; Prognostic predictor; Red cell distribution width (RDW).

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Postoperative cancer-specific survival based on RDW in 144 patients with esophageal cancer
Fig. 2
Fig. 2
Postoperative cancer-specific survival based on RDW in 97 non-elderly patients with esophageal cancer
Fig. 3
Fig. 3
Postoperative cancer-specific survival based on RDW in 47 elderly patients with esophageal cancer
See this image and copyright information in PMC

References

    1. Porrata LF, Ristow K, Colgan JP, et al. Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin’s lymphoma. Haematologica. 2012;97:262–269. doi: 10.3324/haematol.2011.050138. - DOI - PMC - PubMed
    1. Szkandera J, Gerger A, Liegl-Atzwanger B, et al. The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas. Int J Cancer. 2014;135:362–370. doi: 10.1002/ijc.28677. - DOI - PubMed
    1. Hirahara N, Matsubara T, Hayashi H, et al. Impact of inflammation-based prognostic score on survival after curative thoracoscopic esophagectomy for esophageal cancer. Euro J Surg Oncol. 2015;41:1308–1315. doi: 10.1016/j.ejso.2015.07.008. - DOI - PubMed
    1. Forhecz Z, Gombos T, Borgulya G, et al. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J. 2009;158:659–666. doi: 10.1016/j.ahj.2009.07.024. - DOI - PubMed
    1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70. doi: 10.1016/S0092-8674(00)81683-9. - DOI - PubMed

MeSH terms

LinkOut - more resources