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Multicenter Study
. 2016 May;18(5):470-8.
doi: 10.1016/j.hpb.2015.11.005. Epub 2016 Feb 5.

Overuse of surgery in patients with pancreatic cancer. A nationwide analysis in Italy

Gianpaolo Balzano  1 , Giovanni Capretti  2 , Giuditta Callea  3 , Elena Cantù  3 , Flavia Carle  4 , Raffaele Pezzilli  5
Affiliations
Multicenter Study

Overuse of surgery in patients with pancreatic cancer. A nationwide analysis in Italy

Gianpaolo Balzano et al. HPB (Oxford). 2016 May.

Abstract

Background: According to current guidelines, pancreatic cancer patients should be strictly selected for surgery, either palliative or resective.

Methods: Population-based study, including all patients undergoing surgery for pancreatic cancer in Italy between 2010 and 2012. Hospitals were divided into five volume groups (quintiles), to search for differences among volume categories.

Results: There were 544 hospitals performing 10 936 pancreatic cancer operations. The probability of undergoing palliative/explorative surgery was inversely related to volume, being 24.4% in very high-volume hospitals and 62.5% in very low-volume centres (adjusted OR 5.175). Contrarily, the resection rate in patients without metastases decreased from 86.9% to 46.1% (adjusted OR 7.429). As for resections, the mortality of non-resective surgery was inversely related to volume (p < 0.001). Surprisingly, mortality of non-resective surgery was higher than that for resections (8.2% vs. 6.7%; p < 0.01). Approximately 9% of all resections were performed on patients with distant metastases, irrespective of hospital volume group. The excess cost for the National Health System from surgery overuse was estimated at 12.5 million euro.

Discussion: Discrepancies between guidelines on pancreatic cancer treatment and surgical practice were observed. An overuse of surgery was detected, with serious clinical and economic consequences.

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Figures

Figure 1
Figure 1
a: rates of non-resective operations in patients with pancreatic cancer, according to different hospital volumes. b: rates of resective operations in patients without distant metastases, according to different hospital volumes
Figure 2
Figure 2
a: mortality rates of 6570 resections for pancreatic cancer, according to different hospital volumes. b: mortality rates of 4366 non-resective operations (both palliative and exploratory), according to different hospital volumes
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