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. 2016 Jul;142(7):1499-508.
doi: 10.1007/s00432-016-2175-7. Epub 2016 May 7.

Exploring an herbal "wonder cure" for cancer: a multidisciplinary approach

Eran Ben-Arye  1   2   3   4 , Jamal Mahajna  5 , Radi Aly  6 , Mohammed Saleem Ali-Shtayeh  7 , Yedidia Bentur  8 , Efraim Lev  9 , Gary Deng  10 , Noah Samuels  11   12   13
Affiliations

Exploring an herbal "wonder cure" for cancer: a multidisciplinary approach

Eran Ben-Arye et al. J Cancer Res Clin Oncol. 2016 Jul.

Abstract

Context and objectives: The unmonitored use of herbal medicinal remedies by patients with cancer presents a significant challenge to oncology healthcare professionals. We describe an increasingly popular herbal "wonder drug," Ephedra foeminea (Alanda in Arabic), whose use has spread from the Palestinian patient population throughout the Middle East. We conducted a multicentered and multidisciplinary collaborative research effort in order to understand the potential benefits and harms of this popular herbal remedy.

Methods: We conducted an in-depth search of the medical literature, both traditional and modern, for any mention of the clinical use of Alanda for the treatment of cancer. We then tested the remedy, first for toxic ephedra alkaloid components and then for anticancer effects, as well as effects on the cytotoxic activity of chemotherapy agents (cisplatin and carboplatin) on breast cancer cell cultures.

Results: We found no mention in the literature, both conventional and traditional, on the use of Alanda for the treatment of cancer. Laboratory testing did not find any toxic components (i.e., ephedra alkaloids) in the preparation. However, in vitro exposure to Alanda led to a reduced cytotoxic effect of chemotherapy on breast cancer cell cultures.

Conclusions: The use of an integrative ethnobotanical, laboratory and clinical research-based approach can be extremely helpful when providing nonjudgmental and evidence-based guidance to patients with cancer, especially on the use of traditional herbal medicine. The effectiveness and safety of these products need to be examined by integrative physicians who are dually trained in both complementary medicine and supportive cancer care.

Keywords: Complementary medicine; Drug–herb interactions; Ephedra foeminea; Herbal medicine; Integrative medicine; Quality-of-life (QOL).

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Conflict of interest statement

Prof. Eran Ben-Arye declares that he has no conflict of interest. Dr. Jamal Mahajna declares that he has no conflict of interest. Dr. Radi Aly declares that he has no conflict of interest. Dr. Mohammed Saleem Ali-Shtayeh declares that he has no conflict of interest. Prof. Yedidia Bentur declares that he has no conflict of interest. Prof. Efraim Lev declares that he has no conflict of interest. Dr. Gary Deng declares that he has no conflict of interest. Dr. Noah Samuels declares that he has no conflict of interest.

Figures

Fig. 1
Fig. 1
Cross-cultural mapping of the spread of Alanda use among patients with cancer in northern Israel, following a YouTube video on “patient zero” (Palestinian Authority)
Fig. 2
Fig. 2
Ephedra foeminea—GC–MS
Fig. 3
Fig. 3
Approach to establishing evidence-based guidance for the use of Alanda* during chemotherapy
See this image and copyright information in PMC

References

    1. Ali-Shtayeh MS, Jamous RM, Jamous RM (2011) Herbal preparation use by patients suffering from cancer in Palestine. Complement Ther Clin Pract 17(4):235–240 - PubMed
    1. Almog L, Lev E, Schiff E, Linn S, Ben-Arye E (2014) Bridging cross-cultural gaps: monitoring herbal use during chemotherapy in patients referred to integrative medicine consultation in Israel. Support Care Cancer 22(10):2793–2804 - PubMed
    1. Ben-Arye E, Schiff E, Shapira C, Frenkel M, Shalom T, Steiner M (2012) Modeling an integrative oncology program within a community-centered oncology service in Israel. Patient Educ Couns 89(3):423–429 - PubMed
    1. Ben-Arye E, Massalha E, Bar-Sela G, Silbermann M, Agbarya A, Saad B, Lev E, Schiff E (2014a) Stepping from traditional to integrative medicine: perspectives of Israeli-Arab patients on complementary medicine’s role in cancer care. Ann Oncol 25(2):476–480 - PubMed
    1. Ben-Arye E, Halabi I, Attias S, Goldstein L, Schiff E (2014b) Asking patients the right questions about herbal and dietary supplements: cross cultural perspectives. Complement Ther Med 22(2):304–310 - PubMed

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