Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate

Abstract

Background: Severe pulmonary hypertension may following ibuprofen administration for ductal closure.

Case characteristics: An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration.

Outcome: Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications related to bronchopulmonary dysplasia.

Message: Sildenafil may have a role in treatment of severe pulmonary hypertension after ibuprofen treatment for ductal closure.