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. 2016 Jun;26(6):389-390.
doi: 10.1016/j.tcb.2016.04.007. Epub 2016 May 3.

BOK: Oddball of the BCL-2 Family

Elizabeth A Brem  1 , Anthony Letai  2
Affiliations

BOK: Oddball of the BCL-2 Family

Elizabeth A Brem et al. Trends Cell Biol. 2016 Jun.

Abstract

BOK is a BCL-2 family member whose function has been difficult to elucidate. It has been recently demonstrated that BOK is regulated by the endoplasmic reticulum associated-degradation (ERAD) pathway, can induce mitochondrial outer membrane permeabilization (MOMP), and is not regulated by other members of the BCL-2 family. These findings demonstrate a novel mechanism for regulation of apoptosis, but it remains unclear in which specific contexts this mechanism may be most essential for cell death.

Keywords: Bcl-2 family; Bok; ERAD pathway; apoptosis.

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