Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Apr 25:5:F1000 Faculty Rev-738.
doi: 10.12688/f1000research.7898.1. eCollection 2016.

Updates in diabetic peripheral neuropathy

Kelsey Juster-Switlyk  1 , A Gordon Smith  1
Affiliations
Review

Updates in diabetic peripheral neuropathy

Kelsey Juster-Switlyk et al. F1000Res. .

Abstract

Diabetes has become one of the largest global health-care problems of the 21 (st) century. According to the Centers for Disease Control and Prevention, the population prevalence of diabetes in the US is approaching 10% and is increasing by 5% each year. Diabetic neuropathy is the most common complication associated with diabetes mellitus. Diabetes causes a broad spectrum of neuropathic complications, including acute and chronic forms affecting each level of the peripheral nerve, from the root to the distal axon. This review will focus on the most common form, distal symmetric diabetic polyneuropathy. There has been an evolution in our understanding of the pathophysiology and the management of diabetic polyneuropathy over the past decade. We highlight these new perspectives and provide updates from the past decade of research.

Keywords: Diabetes mellitus; diabetic peripheral neuropathy; polyneuropathy.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

No competing interests were disclosed.

References

    1. Hossain P, Kawar B, El Nahas M: Obesity and diabetes in the developing world--a growing challenge. N Engl J Med. 2007;356(3):213–5. 10.1056/NEJMp068177 - DOI - PubMed
    1. Singh R, Kishore L, Kaur N: Diabetic peripheral neuropathy: current perspective and future directions. Pharmacol Res. 2014;80:21–35. 10.1016/j.phrs.2013.12.005 - DOI - PubMed

    2. F1000 Recommendation

    1. Boulton AJ: Management of Diabetic Peripheral Neuropathy. Clin Diabetes. 2005;23(1):9–15. 10.2337/diaclin.23.1.9 - DOI
    1. Tesfaye S, Selvarajah D: Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy. Diabetes Metab Res Rev. 2012;28(Suppl 1):8–14. 10.1002/dmrr.2239 - DOI - PubMed
    1. Tesfaye S, Vileikyte L, Rayman G, et al. : Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev. 2011;27(7):629–38. 10.1002/dmrr.1225 - DOI - PubMed

LinkOut - more resources