Inflammation in Complicated Pregnancy and Its Outcome
- PMID: 27159203
- DOI: 10.1055/s-0036-1582397
Inflammation in Complicated Pregnancy and Its Outcome
Abstract
Background Normal pregnancy relies on a careful balance between immune tolerance and suppression. It is known that strict regulation of maternal immune function, in addition to components of inflammation, is paramount to successful pregnancy, and any imbalance between proinflammatory and anti-inflammatory cytokines and chemokines can lead to aberrant inflammation, often seen in complicated pregnancies. Inflammation in complicated pregnancies is directly associated with increased mortality and morbidity of the mother and offspring. Aberrant inflammatory reactions in complicated pregnancies often lead to adverse outcomes, such as spontaneous abortion, preterm labor, intrauterine growth restriction, and fetal demise. The role of inflammation in different stages of normal pregnancy is reviewed, compared, and contrasted with aberrant inflammation in complicated pregnancies. The complications addressed are preterm labor, pregnancy loss, infection, preeclampsia, maternal obesity, gestational diabetes mellitus, autoimmune diseases, and inflammatory bowel disease. Aim This article examines the role of various inflammatory factors contributing to aberrant inflammation in complicated pregnancies. By understanding the aberrant inflammatory process in complicated pregnancies, novel diagnostic tools and therapeutic interventions for modulating it appropriately can be identified.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Similar articles
-
Inflammation and pregnancy.Reprod Sci. 2009 Feb;16(2):206-15. doi: 10.1177/1933719108329095. Reprod Sci. 2009. PMID: 19208789 Review.
-
Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?Am J Obstet Gynecol. 2018 Feb;218(2S):S762-S773. doi: 10.1016/j.ajog.2017.11.567. Epub 2017 Dec 22. Am J Obstet Gynecol. 2018. PMID: 29275823 Review.
-
Changes in the fetal and neonatal cytokine profile in pregnancies complicated by fetal growth restriction.Am J Reprod Immunol. 2013 May;69(5):441-8. doi: 10.1111/aji.12052. Epub 2012 Dec 24. Am J Reprod Immunol. 2013. PMID: 23278962 Review.
-
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.Am J Obstet Gynecol. 2016 Feb;214(2):287.e1-287.e5. doi: 10.1016/j.ajog.2015.09.093. Epub 2015 Oct 3. Am J Obstet Gynecol. 2016. PMID: 26435047
-
Lymphocyte subsets and autoantibodies in pregnancies complicated by placental disorders.Am J Reprod Immunol. 1995 Jan;33(1):31-9. doi: 10.1111/j.1600-0897.1995.tb01135.x. Am J Reprod Immunol. 1995. PMID: 7619232
Cited by
-
Maternal hepcidin determines embryo iron homeostasis in mice.Blood. 2020 Nov 5;136(19):2206-2216. doi: 10.1182/blood.2020005745. Blood. 2020. PMID: 32584957 Free PMC article.
-
Androgens Upregulate Pathogen-Induced Placental Innate Immune Response.Int J Mol Sci. 2022 Apr 29;23(9):4978. doi: 10.3390/ijms23094978. Int J Mol Sci. 2022. PMID: 35563368 Free PMC article.
-
Macrophage Migration Inhibitory Factor (MIF) Prevents Maternal Death, but Contributes to Poor Fetal Outcome During Congenital Toxoplasmosis.Front Microbiol. 2018 May 8;9:906. doi: 10.3389/fmicb.2018.00906. eCollection 2018. Front Microbiol. 2018. PMID: 29867817 Free PMC article.
-
Obstructive Sleep Apnea in Pregnancy: A Comprehensive Review of Maternal and Fetal Implications.Neurol Int. 2024 May 7;16(3):522-532. doi: 10.3390/neurolint16030039. Neurol Int. 2024. PMID: 38804478 Free PMC article. Review.
-
Longitudinal Assessment of Relationships Between Health Behaviors and IL-6 in Overweight and Obese Pregnancy.Biol Res Nurs. 2021 Jul;23(3):481-487. doi: 10.1177/1099800420985615. Epub 2021 Jan 29. Biol Res Nurs. 2021. PMID: 33511855 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical