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. 1989 Feb;17(1):131-7.
doi: 10.1007/BF01059092.

Estimation of noncompartmental parameters: a technical note

A Dunne  1 , P King
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Estimation of noncompartmental parameters: a technical note

A Dunne et al. J Pharmacokinet Biopharm. 1989 Feb.

Abstract

Noncompartmental pharmacokinetic parameters are usually expressed in terms of the area under the so-called first moment curve and the area under the plasma concentration-time curve. These areas are normally computed by numerical integration. There is an inconsistency in the way in which they are presently estimated. This inconsistency is detailed and a consistent approach to the computation of noncompartmental parameters is outlined. The difference between the two methods is illustrated using some data from the literature.

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References

    1. J Pharm Sci. 1979 Aug;68(8):1071-4 - PubMed
    1. J Pharmacokinet Biopharm. 1978 Feb;6(1):79-98 - PubMed
    1. Comput Programs Biomed. 1983 Jun;16(3):203-16 - PubMed
    1. J Pharmacokinet Biopharm. 1978 Dec;6(6):547-58 - PubMed

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