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Review
. 2016 Jul;27(7):442-445.
doi: 10.1016/j.tem.2016.04.009. Epub 2016 May 6.

Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Daniël H van Raalte  1 , C Bruce Verchere  2
Affiliations
Review

Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Daniël H van Raalte et al. Trends Endocrinol Metab. 2016 Jul.

Abstract

Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.

Keywords: Glucagon-like peptide (GLP)-1 receptor agonists; beta-cell exhaustion; beta-cell protection; chronic treatment; insulin secretion.

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