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. 2017 Jan-Feb;83(1):88-93.
doi: 10.1016/j.bjorl.2016.01.011. Epub 2016 Apr 20.

The role of Onodi cells in sphenoiditis: results of multiplanar reconstruction of computed tomography scanning

Mehmet Senturk  1 , Ibrahim Guler  2 , Isa Azgin  1 , Engin Umut Sakarya  1 , Gultekin Ovet  1 , Necat Alatas  1 , Ismet Tolu  3 , Omer Erdur  4
Affiliations

The role of Onodi cells in sphenoiditis: results of multiplanar reconstruction of computed tomography scanning

Mehmet Senturk et al. Braz J Otorhinolaryngol. 2017 Jan-Feb.

Abstract
in English, Portuguese

Introduction: Onodi cells are the most posterior ethmoid air cells and extend superolateral to the sphenoid sinus. These cells are also intimately related with the sphenoid sinus, optic nerve, and carotid artery. Radiologic evaluation is mandatory to assess for anatomic variations before any treatment modalities related to the sphenoid sinus.

Objective: To evaluate the effect of Onodi cells on the frequency of sphenoiditis.

Methods: A retrospective analysis was performed in 618 adult patients who underwent high-resolution computed tomography between January 2013 and January 2015. The prevalence of Onodi cells and sphenoiditis was evaluated. Whether the presence of Onodi cells leads to an increase in the prevalence of sphenoiditis was investigated.

Results: Onodi cell positivity was observed in 326 of 618 patients and its prevalence was found to be 52.7%. In the study group, 60.3% (n=73) were ipsilaterally (n=21) or bilaterally (n=52) Onodi-positive, whereas 39.7% (n=48) were Onodi-negative (n=35) or only contralaterally Onodi-positive (n=13). Of the control group, 48.3% (n=240) were Onodi-positive and 51.7% (n=257) were Onodi negative. The co-existence of Onodi cells ipsilaterally was observed to increase the identification of sphenoiditis 1.5-fold, and this finding was statistically significant (p<0.05).

Conclusion: The prevalence of sphenoiditis appears to be higher in patients with Onodi cells. However, it is not possible to state that Onodi cells are the single factor that causes this disease. Further studies are needed to investigate contributing factors related to sphenoiditis.

Introdução: As células de Onodi são as células etmoidais mais posteriores, que se prolongam superolateralmente ao seio esfenoidal. Essas células também se encontram em íntima relação com o seio esfenoidal, o nervo óptico e a artéria carótida. Para análise de variações anatômicas antes da implementação de qualquer modalidade terapêutica relacionada ao seio esfenoidal, a avaliação radiológica é obrigatória,

Objetivo: Nosso objetivo foi avaliar o papel das células de Onodi na frequência de esfenoidite.

Método: Em nosso estudo, foi realizada uma análise retrospectiva em 618 pacientes adultos que se submeteram à tomografia computadorizada de alta resolução entre janeiro de 2013 e janeiro de 2015. Avaliamos a prevalência de células de Onodi e de esfenoidite. Investigamos se a presença de células de Onodi leva a um aumento na prevalência de esfenoidite.

Resultados: A positividade para células de Onodi foi observada em 326 de 618 pacientes, e sua prevalência foi de 52,7%. No grupo de estudo, 60,3% (n = 73) eram CO-positivas: ipsilateral (n = 21) ou bilateralmente (n = 52); e 39,7% (n = 48) eram CO-negativas (n = 35) ou apenas contralateralmente CO-positivas (n = 13). No grupo de controle, 48,3% (n = 240) eram CO-positivas; e 51,7% (n = 257) eram CO-negativas. Observamos que a coexistência de CO ipsilateralmente aumentava em 1,5 vezes a associação com esfenoidite, e esse achado foi estatisticamente significante (p < 0,05).

Conclusão: A prevalência de esfenoidite parece ser maior em pacientes com células de Onodi, mas não é possível afirmar que elas são isoladamente o fator causador desta doença. Novos estudos precisam ser realizados para uma investigação dos fatores contributivos relacionados à esfenoidite.

Keywords: Anatomic variation; Computed tomography; Célula de Onodi; Esfenoidite; Onodi cell; Sphenoiditis; Tomografia computadorizada; Variação anatômica.

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Figures

Figure 1
Figure 1
A coronal CT scan of the paranasal sinuses shows (a) sagittal image an Onodi cell; (b) coronal image of a left Onodi cell; (c) coronal image of a right Onodi cell; (d) coronal image of bilateral Onodi cells (arrow, Onodi cells; asterisk, sphenoid sinuses).
Figure 2
Figure 2
The CT scans of the paranasal sinuses shows bilateral sphenoiditis (arrows).
Figure 3
Figure 3
The graph shows that Onodi cell positivity causes a 1.5-fold increase in the number of cases with sphenoiditis (p = 0.018).
See this image and copyright information in PMC

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