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. 2016 Apr 27;7(7):831-6.
doi: 10.7150/jca.14573. eCollection 2016.

The Reduction in Circulating Melatonin Level May Contribute to the Pathogenesis of Ovarian Cancer: A Retrospective Study

Min Zhao  1 , Jiayi Wan  2 , Ke Zeng  3 , Mancy Tong  4 , Arier C Lee  5 , Jinxin Ding  6 , Qi Chen  7
Affiliations

The Reduction in Circulating Melatonin Level May Contribute to the Pathogenesis of Ovarian Cancer: A Retrospective Study

Min Zhao et al. J Cancer. .

Abstract

Ovarian cancer is the third most common gynaecological malignancy. Changes in circadian rhythms such as bright light exposure may affect female reproductive physiology. Night shift work is associated with higher risks of developing gynaecological cancers. In addition, the season of birth is also suggested as an important environmental risk factor for developing gynaecological cancers. Melatonin may play an important role in this association as a marker of circadian rhythms. Serum from 96 women with ovarian cancer and 40 healthy women were collected and the level of melatonin was measured. In addition 277 women with ovarian cancer and 1076 controls were retrospectively collected for season of birth analysis over seven years. The serum levels of melatonin were significantly lower in women with ovarian cancer compared with healthy women (p<0.05). However there was no difference in melatonin levels in perimenopausal and postmenopausal patients. In addition, there is no statistically significant difference in seasonal distribution of birth between ovarian cancer patients and the control group. The melatonin levels in ovarian cancer patients and controls were not associated with the season of birth. Our results demonstrate the lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer. The incidence of ovarian cancer was not associated with the season of birth. The serum levels of melatonin do not appear to be associated with season of birth in ovarian cancer patients.

Keywords: melatonin; menopause.; ovarian cancer; season of birth.

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Figures

Figure 1
Figure 1
The serum levels of melatonin were significantly reduced in women with ovarian cancer at diagnosis compared to healthy women (p=0.001).
Figure 2
Figure 2
The serum levels of melatonin were not different between perimenopausal women with ovarian cancer and postmenopausal women with ovarian cancer (p=0.274).
Figure 3
Figure 3
The serum levels of melatonin were not different between ovarian cancer patients with peritoneal metastasis and without peritoneal metastasis (p=0.356).
See this image and copyright information in PMC

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References

    1. Edwards B.K, Brown M.L, Wingo P.A, Howe H.L, Ward E, Ries L.A.G, Schrag D, Jamison P.M, Jemal A, Wu X.C. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. Journal of the National Cancer Institute. 2005;97(19):1407. - PubMed
    1. Reiter R.J, Tamura H, Tan D.X, Xu X.Y. Melatonin and the circadian system: contributions to successful female reproduction. Fertil Steril. 2014;102(2):321–8. - PubMed
    1. Lie J.A, Roessink J, Kjaerheim K. Breast cancer and night work among Norwegian nurses. Cancer Causes Control. 2006;17(1):39–44. - PubMed
    1. Hansen J. Increased breast cancer risk among women who work predominantly at night. Epidemiology. 2001;12(1):74–7. - PubMed
    1. Davis S, Mirick D.K, Stevens R.G. Night shift work, light at night, and risk of breast cancer. J Natl Cancer Inst. 2001;93(20):1557–62. - PubMed

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