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Review
. 2016 May 10;7(9):177-88.
doi: 10.4239/wjd.v7.i9.177.

Positive evidence for vitamin A role in prevention of type 1 diabetes

Somaye Yosaee  1 , Maryam Akbari Fakhrabadi  1 , Farzad Shidfar  1
Affiliations
Review

Positive evidence for vitamin A role in prevention of type 1 diabetes

Somaye Yosaee et al. World J Diabetes. .

Abstract

Type 1 diabetes mellitus (T1DM) as one of the most well-known autoimmune disease, results from the destruction of β-cells in pancreas by autoimmune process. T1DM is fatal without insulin treatment. The expansion of alternative treatment to insulin is a dream to be fulfilled. Currently autoimmunity is considered as main factor in development of T1DM. So manipulation of the immune system can be considered as alternative treatment to insulin. For the past decades, vitamin A has been implicated as an essential dietary micronutrient in regulator of immune function. Despite major advantage in the knowledge of vitamin A biology, patients who present T1DM are at risk for deficiency in vitamin A and carotenoids. Applying such evidences, vitamin A treatment may be the key approach in preventing T1DM.

Keywords: Autoimmune; Diabetes; Insulin; Pancreas; Vitamin A.

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Figures

Figure 1
Figure 1
Schematic diagram for the pathways of vitamin A effects on innate immune system. NK: Natural killer; TNF: Tumor necrosis factors; IL: Interleukin; MoDCs: Monocyte-derived dendritic cells.
Figure 2
Figure 2
Immunology of type 1 diabetes[115]. TNF: Tumor necrosis factors; IL: Interleukin; MoDCs: Monocyte-derived dendritic cells; APCs: Antigen presenting cells; IFN: Interferon; HLA: Human leukocyte antigen.
See this image and copyright information in PMC

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