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Review
. 2016 Apr;4(7):135.
doi: 10.21037/atm.2016.03.40.

Circulating miR-499 as a potential biomarker for acute myocardial infarction

Yunyi Xin  1 , Chengjian Yang  1 , Zhijun Han  1
Affiliations
Review

Circulating miR-499 as a potential biomarker for acute myocardial infarction

Yunyi Xin et al. Ann Transl Med. 2016 Apr.

Abstract

Acute myocardial infarction (AMI), a common heart disease that may lead to chronic heart failure, is the leading cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) are small non-coding RNAs that mediate the expression of target genes. Recently, a number of miRNAs are emerging as potential biomarkers of AMI. MiRNA-499 is a newly discovered member of miRNAs, and is mainly expressed in myocardium, the circulating levels of miRNA-499 was increased in AMI patients. This review summarizes the latest advances in the miRNA-499 study and discusses the potential of miRNA-499 to be a biomarker of AMI.

Keywords: Acute myocardial infarction (AMI); biomarker; miRNA-499.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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