Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun 24;1(3):117-23.
doi: 10.1021/acscentsci.5b00182. Epub 2015 Jun 9.

Biological Responses to Engineered Nanomaterials: Needs for the Next Decade

Catherine J Murphy  1 , Ariane M Vartanian  1 , Franz M Geiger  2 , Robert J Hamers  3 , Joel Pedersen  3 , Qiang Cui  3 , Christy L Haynes  4 , Erin E Carlson  4 , Rigoberto Hernandez  5 , Rebecca D Klaper  6 , Galya Orr  7 , Ze'ev Rosenzweig  8
Affiliations
Review

Biological Responses to Engineered Nanomaterials: Needs for the Next Decade

Catherine J Murphy et al. ACS Cent Sci. .

Abstract

The interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The promise of nanotechnology to improve human health includes diagnostics, drug delivery, imaging, and therapy.
Figure 2
Figure 2
Nanoparticles interact with biological systems at the molecular, cellular, organismal, and ecosystem levels.
Figure 3
Figure 3
Interactions between nanoparticles that are chemically complex and biological “receptors” need to be understood at a molecular level.
Figure 4
Figure 4
Computational approaches to understanding the nano–bio interface span orders of magnitude in time and space.
See this image and copyright information in PMC

References

    1. Roco M., Bainbridge W. S., Eds. Nanotechnology: Societal implications I; Maximizing benefits for humanity; Springer: Dordrecht, The Netherlands, 2007.
    1. Alivisatos A. P. Semiconductor clusters, nanocrystals, and quantum dots. Science 1996, 271, 933–937.
    1. Kelly K. L.; Coronado E.; Zhao L. L.; Schatz G. C. The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J. Phys. Chem. B 2003, 107, 668–677.
    1. Burda C.; Chen X.; Narayanan R.; El-Sayed M. A. Chemistry and properties of nanocrystals of different shapes. Chem. Rev. 2005, 105, 1025–1102. - PubMed
    1. Liversidge G. G.; Cundy K. C. Particle-size reduction for improvement of oral bioavailability of hydrophobic drugs. 1. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int. J. Pharm. 1995, 125, 91–97.

LinkOut - more resources