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Review
. 2016 May 5;17(5):650.
doi: 10.3390/ijms17050650.

Interaction between Mesenchymal Stem Cells and B-Cells

Linxiao Fan  1 , Chenxia Hu  2 , Jiajia Chen  3 , Panpan Cen  4 , Jie Wang  5 , Lanjuan Li  6
Affiliations
Review

Interaction between Mesenchymal Stem Cells and B-Cells

Linxiao Fan et al. Int J Mol Sci. .

Abstract

Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.

Keywords: B-cell; T-cell; cytokine; graft-versus-host disease; immune regulation; immune suppression; mesenchymal stem cell; plasma cell; systemic lupus erythematous.

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Figures

Figure 1
Figure 1
When MSCs are co-cultured with B-cells in basic condition, MSCs regulate Igs-secreting, apoptosis, proliferation, plasma-cell differentiation and chemotaxis of B-cells. For indefinite reasons, such as diverse stimulators of B-cells in culture medium, regulations of proliferation, plasma-cell differentiation and Igs secreting of B-cells are unable to reach agreement.
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