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. 2016 Sep;43(10):1849-56.
doi: 10.1007/s00259-016-3397-2. Epub 2016 May 11.

Laparoscopic sentinel lymph node dissection in prostate cancer patients: the additional value depends on preoperative data

Caroline Rousseau  1   2 , Thierry Rousseau  3 , Cédric Mathieu  4 , Jacques Lacoste  3 , Eric Potiron  3 , Geneviève Aillet  5 , Pierre Nevoux  3 , Georges Le Coguic  3 , Loïc Campion  6   7 , Françoise Kraeber-Bodéré  4   6
Affiliations

Laparoscopic sentinel lymph node dissection in prostate cancer patients: the additional value depends on preoperative data

Caroline Rousseau et al. Eur J Nucl Med Mol Imaging. 2016 Sep.

Abstract

Aim: In intermediate- or high-risk prostate cancer (PC) patients, to avoid extended pelvic lymph node dissection (ePLND), the updated Briganti nomogram is recommended with the cost of missing 1.5 % of patients with lymph node invasion (LNI). Is it possible to reduce the percentage of unexpected LNI patients (nomogram false negative)? We used the isotopic sentinel lymph node (SLN) technique systematically associated with laparoscopic ePLND to assess the potential value of isotopic SLN method to adress this point.

Methods: Two hundred and two consecutive patients had procedures with isotopic SLN detection associated with laparoscopic ePLND for high or intermediate risk of PC. The area under the curve (AUC) of the receiver operating characteristics (ROC) analysis was used to quantify the accuracy of different models as: the updated Briganti nomogram, the percentage of positive cores, and an equation of the best predictors of LNI. We tested the model cutoffs associated with an optimal negative predictive value (NPV) and the best cutoff associated with avoiding false negative SLN detection, in order to assist the clinician's decision of when to spare ePLND.

Results: LNI was detected in 35 patients (17.2 %). Based on preoperative primary Gleason grade and percentage of positive cores, a bivariate model was built to calculate a combined score reflecting the risk of LNI. For the Briganti nomogram, the 5 % probability cutoff avoided ePLND in 53 % (108/202) of patients, missing three LNI patients (8.6 %), but all were detected by the SLN technique. For our bivariate model, the best cutoff was <10, leaving no patient with LNI due to positive SLN detection (four patients = 11.4 %), and avoiding ePLND in 52 % (105/202) of patients.

Conclusion: For patients with a low risk of LNI determined using the updated Briganti nomogram or bivariate model, SLN technique could be used alone for lymph node staging in intermediate- or high-risk PC patients.

Keywords: Laparoscopic surgery; Nomogram; Prostate cancer; Sentinel lymph node.

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