Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;160(6):779-82.
doi: 10.1007/s10517-016-3308-3. Epub 2016 May 11.

Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis

E A Blinova  1 , E V Zinnatova  2 , M Sh Barkovskaya  2 , V I Borisov  2 , A E Sizikov  2 , V S Kozhevnikov  2 , N B Rubtsov  3 , V A Kozlov  2
Affiliations

Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis

E A Blinova et al. Bull Exp Biol Med. 2016 Apr.

Abstract

We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.

Keywords: chromosomes; lymphocytes; quantitative fluorescent in situ hybridization; rheumatoid arthritis; telomere length.

PubMed Disclaimer

LinkOut - more resources