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. 2016 Aug;6(4):217-23.
doi: 10.1007/s13659-016-0099-1. Epub 2016 May 10.

Characterization of New Ent-kaurane Diterpenoids of Yunnan Arabica Coffee Beans

Rui Chu  1   2 , Luo-Sheng Wan  1 , Xing-Rong Peng  1 , Mu-Yuan Yu  1   2 , Zhi-Run Zhang  1 , Lin Zhou  1 , Zhong-Rong Li  1 , Ming-Hua Qiu  3   4
Affiliations

Characterization of New Ent-kaurane Diterpenoids of Yunnan Arabica Coffee Beans

Rui Chu et al. Nat Prod Bioprospect. 2016 Aug.

Abstract

Five new ent-kaurane diterpenoids, named mascaroside III-V (1-3), and 20-nor-cofaryloside I-II (4-5), together with seven known diterpenoids, were isolated from methanol extracts of the green coffee beans of Yunnan Arabica Coffee. Their chemical structures were elucidated by extensive spectroscopic analyses. Meanwhile, cytotoxicity assay against HL-60, A-549, SMMC-7721, MCF-7 and SW480 cell lines showed that they have not evident inhibition of cytotoxicity.

Keywords: Coffea arabica L.; Diterpenoids; Green coffee beans; Structural elucidation.

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Figures

Fig. 1
Fig. 1
Structures of compounds 1–12
Fig. 2
Fig. 2
Key correlations in 2D NMR spectra of compound 1
Fig. 3
Fig. 3
Key correlations in 2D NMR spectra of compound 4
Fig. 4
Fig. 4
Key correlations in 2D NMR spectra of compound 5
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