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Comment
. 2016 May 9;29(5):619-621.
doi: 10.1016/j.ccell.2016.04.010.

Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma

Colin R Goding  1
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Free article
Comment

Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma

Colin R Goding. Cancer Cell. .
Free article

Abstract

In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 status.

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  • Melanoma addiction to the long non-coding RNA SAMMSON.
    Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC. Leucci E, et al. Nature. 2016 Mar 24;531(7595):518-22. doi: 10.1038/nature17161. Nature. 2016. PMID: 27008969

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