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. 2016 Jul;26(7):471-473.
doi: 10.1016/j.tcb.2016.04.010. Epub 2016 May 7.

25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details

W James Nelson  1 , William I Weis  2
Affiliations

25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details

W James Nelson et al. Trends Cell Biol. 2016 Jul.

Abstract

Over the past 25 years, there has been a conceptual (re)evolution in understanding how the cadherin cell adhesion complex, which contains F-actin-binding proteins, binds to the actin cytoskeleton. There is now good synergy between structural, biochemical, and cell biological results that the cadherin-catenin complex binds to F-actin under force.

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