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Comment
. 2016 Jun;37(6):349-351.
doi: 10.1016/j.it.2016.04.008. Epub 2016 May 8.

Tumor Heterogeneity and Tumor Immunity: A Chicken-and-Egg Problem

Stefani Spranger  1
Affiliations
Comment

Tumor Heterogeneity and Tumor Immunity: A Chicken-and-Egg Problem

Stefani Spranger. Trends Immunol. 2016 Jun.

Abstract

The overall mutational burden of a tumor is considered to be a predictive marker for the success of checkpoint blockade therapy. A recent study by McGranahan et al. reframes this notion by showing that clonal expression of neoantigens by tumor cells, rather than overall mutational burden, determines the response to checkpoint blockade therapy.

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Comment on

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
    McGranahan N, Furness AJ, Rosenthal R, Ramskov S, Lyngaa R, Saini SK, Jamal-Hanjani M, Wilson GA, Birkbak NJ, Hiley CT, Watkins TB, Shafi S, Murugaesu N, Mitter R, Akarca AU, Linares J, Marafioti T, Henry JY, Van Allen EM, Miao D, Schilling B, Schadendorf D, Garraway LA, Makarov V, Rizvi NA, Snyder A, Hellmann MD, Merghoub T, Wolchok JD, Shukla SA, Wu CJ, Peggs KS, Chan TA, Hadrup SR, Quezada SA, Swanton C. McGranahan N, et al. Science. 2016 Mar 25;351(6280):1463-9. doi: 10.1126/science.aaf1490. Epub 2016 Mar 3. Science. 2016. PMID: 26940869 Free PMC article.

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