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. 2016 May 24;52(44):7114-7.
doi: 10.1039/c5cc08325g.

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Shubhanchi Nigam  1 , Benjamin P Burke  1 , Laura H Davies  2 , Juozas Domarkas  3 , Jennifer F Wallis  2 , Paul G Waddell  2 , Jennifer S Waby  4 , David M Benoit  5 , Anne-Marie Seymour  6 , Christopher Cawthorne  7 , Lee J Higham  2 , Stephen J Archibald  1
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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Shubhanchi Nigam et al. Chem Commun (Camb). .

Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

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