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Comment
. 2016 May 10;23(5):759-61.
doi: 10.1016/j.cmet.2016.04.018.

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis

Shabnam Shalapour  1 , Michael Karin  2
Affiliations
Free article
Comment

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis

Shabnam Shalapour et al. Cell Metab. .
Free article

Abstract

A new study has added loss of CD4(+) T cells caused by aberrant lipid metabolism to the list of mechanisms promoting nonalcoholic steatohepatitis progression to liver cancer (Ma et al., 2016). Exposure of CD4(+) T cells to free linoleic acid causes their ROS-mediated depletion, thereby favoring liver cancer growth.

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  • NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
    Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. Ma C, et al. Nature. 2016 Mar 10;531(7593):253-7. doi: 10.1038/nature16969. Epub 2016 Mar 2. Nature. 2016. PMID: 26934227 Free PMC article.

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