Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jan-Mar;5(1):5-7.
doi: 10.4103/2278-330X.179699.

The relationship between histologic grades of invasive carcinoma of breast ducts and mast cell infiltration

Ashraf Fakhrjou  1 , Mohammad Naghavi-Behzad  2 , Vahid Montazeri  3 , Farid Karkon-Shayan  4 , Leila Norouzi-Panahi  5 , Reza Piri  6
Affiliations

The relationship between histologic grades of invasive carcinoma of breast ducts and mast cell infiltration

Ashraf Fakhrjou et al. South Asian J Cancer. 2016 Jan-Mar.

Erratum in

Abstract

Introduction: Breast carcinoma is the most prevalent tumors among women. Transformation of inflated cells in immune response leads to increase in inflammatory cells such as macrophages, mast cells (MC) and fibroblasts. The aim of this study was to determine the relationship between grades of invasive carcinoma of the breast ducts and MC infiltration around tumoral cells.

Methods: During the present study, 75 female patients suffering from invasive ductal carcinoma who underwent surgery or diagnostic biopsy during 2010 and 2013 in Educational-Medical centers of Tabriz University of Medical Sciences, were included in the study. Based on Bloom-Richardson grading system, 25 cases were selected from each grade. To better observe of MCs, samples were stained by Toluidine blue and MCs were counted in 10 40 × 10 fields.

Results: The mean age was 47.56 ± 10.84 and the number of MCs was between 6 and 96 and their overall average was 43.01. Average count of MCs in grade 1, 2 and 3 were 15.92 ± 10.07, 45.32 ± 10.47, and 67.8 ± 20.70, respectively. There was a significant relationship between the number of MCs and increase in disease grade (P < 0.001). With increasing grade of malignancy, the number of MCs had grown. No significant relationship was observed between age and grade of disease or age and number of MC.

Conclusion: According to obtained results, number of MC around tumoral cells increased significantly with an increase in the grade of disease. In order to treat in the first stages of the disease, recognizing primary changes in the stroma of cells could be helpful.

Keywords: Breast cancer; histopathological grade; invasive ductal carcinoma; mast cell.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Required steps for fixing sample with 10% paraffin
Figure 2
Figure 2
Relationship between age and mast cell in breast ductal carcinoma patients
See this image and copyright information in PMC

References

    1. Fauci AS. Harrison's Principles of Internal Medicine. Vol. 2. New York: McGraw-Hill Medical; 2008.
    1. Mohammadzadeh M, Pourzand A, Eftekhar-Sadat AT, Alikhah H, Naghavi-Behzad M. A case of concurrent several forms of thyroid cancer. Niger Med J. 2013;54:351–3. - PMC - PubMed
    1. Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology: With Student Consult Online Access. Philadelphia: Elsevier Health Sciences; 2011.
    1. Theoharides TC, Alysandratos KD, Angelidou A, Zhang B. The Tumor Microenvironment. New York: Springer; 2010. Mast cells and tumor microenvironment; pp. 353–70.
    1. Della Rovere F, Granata A, Familiari D, D’Arrigo G, Mondello B, Basile G. Mast cells in invasive ductal breast cancer: Different behavior in high and minimum hormone-receptive cancers. Anticancer Res. 2007;27:2465–71. - PubMed