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Review
. 2016 Jul;16(7):61.
doi: 10.1007/s11910-016-0668-z.

Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis

Rebecca L Hurst  1 , Clifton L Gooch  2   3
Affiliations
Review

Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis

Rebecca L Hurst et al. Curr Neurol Neurosci Rep. 2016 Jul.

Abstract

Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated neuromuscular disease and is characterized by a decrease in the number of functional acetylcholine receptors (AChR) within the muscle end plate zone of the neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated myasthenia gravis has been extensively studied over the last 40 years since its original description by Patrick and Lindstrom (Science 180:871-872, 1973), less is known about the much more recently described muscle-specific kinase (MuSK) antibody-mediated MG. MuSK-MG has features clinically distinct from Ach-R MG, as well as a different pattern of response to treatment and a unique immunopathogenesis.

Keywords: Acetylcholine receptor antibody; Muscle-specific receptor tyrosine kinase; Myasthenia gravis; Neuromuscular junction.

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References

    1. Lancet Neurol. 2009 May;8(5):475-90 - PubMed
    1. Lancet Neurol. 2003 Feb;2(2):99-106 - PubMed
    1. Nat Med. 2001 Mar;7(3):365-8 - PubMed
    1. Neurology. 2005 Nov 8;65(9):1508-9 - PubMed
    1. Orphanet J Rare Dis. 2007 Nov 06;2:44 - PubMed

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