Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep;2(1):36-9.
doi: 10.1159/000436973. Epub 2015 Jul 15.

Orbital Paraganglioma and Succinate Dehydrogenase Staining for Genetic Testing Triage and Prognosis

Cesar M Salinas-La Rosa  1
Affiliations

Orbital Paraganglioma and Succinate Dehydrogenase Staining for Genetic Testing Triage and Prognosis

Cesar M Salinas-La Rosa. Ocul Oncol Pathol. 2015 Sep.

Abstract

Purpose of the study: To describe the rare occurrence of a paraganglioma in the orbit and how to triage for genetic testing and assess the prognosis with succinate dehydrogenase subunit B (SDHB) immunohistochemical staining.

Method: Case report.

Procedures: A 47-year-old 'healthy' male presented with painless exophthalmos and diplopia secondary to an infraorbital tumour mass.

Results: The orbital biopsy was diagnosed as paraganglioma with positive staining with SDHB.

Conclusion: The rarity of an orbital paraganglioma was followed by the clinical search for a possible occult extraorbital primary paraganglioma. SDHB staining helped in the triage for genetic testing and gave an idea about the prognosis for this tumour.

Keywords: Familial syndrome; Orbit; Paraganglioma; Succinate dehydrogenase immunohistochemical stain.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
a-g Orbital paraganglioma. a CT scan with an enhancing mass inferior to the right globe measuring 13 × 13 mm, abutting the right canal and causing mild upward globe displacement. b Nests of polygonal cells on a vascularised stroma, consistent with paraganglioma. HE. ×200. c Nests of polygonal cells on a vascularised stroma, consistent with paraganglioma. HE. ×400. d Paraganglioma cells positive for chromogranin immunohistochemical stain. ×400. e Paraganglioma cells positive for synaptophysin immunohistochemical stain. ×400. f Sustentacular cells highlighted with S100 immunohistochemical stain. g SDH immunohistochemical stain (red) with granular cytoplasmic staining in paraganglioma tumour cells with a positive internal control in endothelial cells (CD31, brown), a pattern of staining consistent with a positive result. ×400.
See this image and copyright information in PMC

References

    1. Sharma MC, Epari S, Gaikwad S, Verma A, Sarkar C. Orbital paraganglioma: report of a rare case. Can J Ophthalmol. 2005;40:640–644. - PubMed
    1. Hill RH, 3rd, Platt SM, Bersani A, Barker-Griffith A, Strumpf K. Regression of a paraganglioma tumor of the orbit. Orbit. 2015;34:99–102. - PubMed
    1. Bedner MM, Trainer TD, Aitken PA, Grenko R, Dorwart R, Duckworth J, Gross CE, Pendlebury WW. Orbital paraganglioma: case report and review of the literature. Br J Ophthalmol. 1992;76:183–185. - PMC - PubMed
    1. Bagheri A, Aletha M, Salour H, Abdollahi A, Silbert D, Rezaei-Kanavi M. Orbital paraganglioma presenting as lateral rectus enlargement and its novel management: a case report and review of the literature. Orbit. 2012;31:256–260. - PubMed
    1. Makhdoomi R, Nayil K, Santosh V, Kumar S. Orbital paraganglioma: a case report and review of the literature. Clin Neuropatol. 2010;29:100–104. - PubMed