Adenoma of the Nonpigmented Ciliary Body and Iris Epithelium in Mexican Mestizo Patients

Abstract

The adenoma of the nonpigmented ciliary epithelium is a benign rare tumor, which may present with different clinical characteristics and requires resection along with histopathologic analysis and the identification of specific immunohistochemical markers for an accurate diagnosis. Here, we report a case series of 4 patients in a Mexican mestizo population with this diagnosis, their clinical features, the ultrasound imaging characteristics and the histopathological and immunohistochemical findings.

Keywords: Adenoma of the nonpigmented ciliary epithelium; Immunohistochemistry; Sclerouvectomy.

Fig. 1

a Case 1: inferior exudative retinal detachment with an associated nodular hypopigmented lesion in the extreme retinal periphery. b Case 2: round, slightly elevated and barely vascularized lesion, arising from the inferior peripheral iris stroma 11 months after initial presentation. c Case 3: hypopigmented, nodular lesion behind the iris touching the lens. d Case 4: inferotemporal, hypopigmented lesion arising from the margin of the iris.

Fig. 2

a Case 1: B-mode ultrasound showing a solid mass of homogeneous density, measuring 7 × 6 mm, associated with retinal detachment. b Case 1: standardized A-mode echography demonstrating high internal reflectivity. c Case 2: ultrasound biomicroscopy at presentation showing a homogeneous lesion of 2 × 3 mm with corneal endothelial touch but without lens contact. d Case 4: ultrasound biomicroscopy showing the mass displacing the iris forward.

Fig. 3

Case 1: photomicrograph of the tumor showing diffuse and strong cytoplasmic positivity for S-100 (a), vimentin (b), EMA (c), and NSE (d).