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. 2017 Apr;77(4):1650-1655.
doi: 10.1002/mrm.26256. Epub 2016 May 12.

Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13 C,15 N-Urea

Lotte B Bertelsen  1 , Per M Nielsen  1 , Haiyun Qi  1 , Thomas S Nørlinger  1 , Xiaolu Zhang  1 , Hans Stødkilde-Jørgensen  1 , Christoffer Laustsen  1
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Free article

Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13 C,15 N-Urea

Lotte B Bertelsen et al. Magn Reson Med. 2017 Apr.
Free article

Abstract

Purpose: In the current study, we investigated hyperpolarized urea as a possible imaging biomarker of the renal function by means of the intrarenal osmolality gradient.

Methods: Hyperpolarized three-dimensional balanced steady state 13 C MRI experiments alongside kidney function parameters and quantitative polymerase chain reaction measurements was performed on two groups of rats, a streptozotocin type 1 diabetic group and a healthy control group.

Results: A significant decline in intrarenal steepness of the urea gradient was found after 4 weeks of untreated insulinopenic diabetes in agreement with an increased urea transport transcription.

Conclusion: MRI and hyperpolarized [13 C,15 N]urea can monitor the changes in the corticomedullary urea concentration gradients in diabetic and healthy control rats. Magn Reson Med 77:1650-1655, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Keywords: MRI; Type 1 diabetes; hyperpolarization; kidney; renal function.

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