Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug 2;12(8):1960-1964.
doi: 10.1080/21645515.2016.1160178. Epub 2016 May 12.

Is HPV vaccination in pregnancy safe?

Ulla Bonde  1   2 , Jan Stener Joergensen  1   2 , Ronald F Lamont  1   2   3 , Ole Mogensen  1   2
Affiliations
Review

Is HPV vaccination in pregnancy safe?

Ulla Bonde et al. Hum Vaccin Immunother. .

Abstract

Millions of doses of HPV vaccine have been administered globally. Inadvertent administration of HPV vaccine during pregnancy occurs given that the main recipients of the vaccine are fertile young women, who might be unaware of their pregnancy at the time of their vaccination. To investigate the subject of HPV vaccine and pregnancy , the databases of PubMed and Embase were searched to find the relevant literature published in English within the last 10 y. Most of the evidence pertaining to fetal adverse events following HPV vaccination relates to spontaneous miscarriage. None of the relevant studies found any significantly increased rate of spontaneous abortion in the overall analyses. There was no indication of other HPV vaccine-associated adverse events in pregnancy or immediately post-conception.

Keywords: HPV; adverse events; pregnancy; spontaneous abortion; vaccine.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Flow Chart of the Systematic Literature Search.
See this image and copyright information in PMC

References

    1. al. Fe Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International journal of Cancer 2015; 136(5):E359-86. http://dx.doi.org/ 10.1002/ijc.29210; Epub 2014 Oct 9. - DOI - PubMed
    1. de Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, Tous S, Felix A, Bravo LE, Shin HR, et al.. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol 2010; 11:1048-56; PMID:20952254; http://dx.doi.org/ 10.1016/S1470-2045(10)70230-8 - DOI - PubMed
    1. Poland GA, Jacobson RM, Koutsky LA, Tamms GM, Railkar R, Smith JF, Bryan JT, Cavanaugh PF Jr., Jansen KU, Barr E. Immunogenicity and reactogenicity of a novel vaccine for human papillomavirus 16: a 2-year randomized controlled clinical trial. Mayo Clin Proc 2005; 80:601-10; PMID:15887427; http://dx.doi.org/ 10.4065/80.5.601 - DOI - PubMed
    1. Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, Moreira ED Jr., Ngan Y, Petersen LK, Lazcano-Ponce E, et al.. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. N Engl J Med 2015; 372:711-23; PMID:25693011; http://dx.doi.org/ 10.1056/NEJMoa1405044 - DOI - PubMed
    1. Human papillomavirus vaccines: WHO position paper, October 2014 Releve epidemiologique hebdomadaire / Section d'hygiene du Secretariat de la Societe des Nations = Weekly epidemiological record / Health Section of the Secretariat of the League of Nations 2014; 89(43): 465-91. - PubMed

MeSH terms

Substances

LinkOut - more resources