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Comment
. 2016 May 11;19(5):570-1.
doi: 10.1016/j.chom.2016.04.023.

HLA-C Downmodulation by HIV-1 Vpu

Edward Barker  1 , David T Evans  2
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Free article
Comment

HLA-C Downmodulation by HIV-1 Vpu

Edward Barker et al. Cell Host Microbe. .
Free article

Abstract

It is widely held that HIV-1 Nef downmodulates HLA-A and -B to protect infected cells from CD8(+) T cells but leaves HLA-C on the cell surface to inhibit NK cells. In this issue of Cell Host & Microbe, Apps et al. (2016) revise this model by showing that the Vpu protein of primary HIV-1 isolates downmodulate HLA-C.

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  • HIV-1 Vpu Mediates HLA-C Downregulation.
    Apps R, Del Prete GQ, Chatterjee P, Lara A, Brumme ZL, Brockman MA, Neil S, Pickering S, Schneider DK, Piechocka-Trocha A, Walker BD, Thomas R, Shaw GM, Hahn BH, Keele BF, Lifson JD, Carrington M. Apps R, et al. Cell Host Microbe. 2016 May 11;19(5):686-95. doi: 10.1016/j.chom.2016.04.005. Cell Host Microbe. 2016. PMID: 27173934 Free PMC article.

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