Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents

Abstract

Objective: To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents.

Study design: In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging.

Results: When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all Pquadratic < .05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (Plinear = .03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight.

Conclusions: Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.

Keywords: fetal origins; insulin resistance; metabolic syndrome; obesity.

Figure

Associations of A, SAAT and B, VAT across tertiles of birth weight in 575 adolescents aged 14–18 years. P_linear and P_quadratic refer to P values obtained from the ANCOVA analysis for linear and quadratic terms, respectively, adjusted for age, sex, Tanner stage, moderate/vigorous physical activity, socioeconomic status, and BMI percentile.