Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017;15(1):184-194.
doi: 10.2174/1570159x13666160512150918.

Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape

Kenneth Blum  1 , Marcelo Febo, Rajendra D Badgaiyan, Zsolt Demetrovics, Thomas Simpatico, Claudia Fahlke, Oscar-Berman M, Mona Li, Kristina Dushaj, Mark S Gold
Affiliations
Review

Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape

Kenneth Blum et al. Curr Neuropharmacol. 2017.

Abstract

Background: In 1990, Blum and associates provided the first confirmed genetic link between the DRD2 polymorphisms and alcoholism. This finding was based on an earlier conceptual framework, which served as a blueprint for their seminal genetic association discovery they termed "Brain Reward Cascade." These findings were followed by a new way of understanding all addictive behaviors (substance and non-substance) termed "Reward Deficiency Syndrome" (RDS). RDS incorporates a complex multifaceted array of inheritable behaviors that are polygenic.

Objective: In this review article, we attempt to clarify these terms and provide a working model to accurately diagnose and treat these unwanted behaviors.

Method: We are hereby proposing the development of a translational model we term "Reward Deficiency Solution System™" that incorporates neurogenetic testing and meso-limbic manipulation of a "hypodopaminergic" trait/state, which provides dopamine agonistic therapy (DAT) as well as reduced "dopamine resistance," while embracing "dopamine homeostasis."

Result: The result is better recovery and relapse prevention, despite DNA antecedents, which could impact the recovery process and relapse. Understanding the commonality of mental illness will transform erroneous labeling based on symptomatology, into a genetic and anatomical etiology. WC: 184.

PubMed Disclaimer

References

    1. Physiology or Medicine for 2000. Press Release Nobelprize.org. Nobel Media AB 2014 Webhttp://www.nobelprize.org/nobelprizes/ medicine/laureates/2000/press.html . 2000. Apr 6.
    1. Fahn S. The medical treatment of Parkinson disease from James Parkinson to George Cotzias. Mov. Disord. 2015;30(1):4–18. [http://dx.doi.org/10.1002/mds.26102]. [PMID: 25491387]. - PubMed
    1. Kemp D.E. Managing the side effects associated with commonly used treatments for bipolar depression. J. Affect. Disord. 2014;169(Suppl. 1):S34–S44. [http://dx.doi.org/10.1016/S0165-0327(14) 70007-2]. [PMID: 25533913]. - PubMed
    1. Furukawa T.A., Levine S.Z., Tanaka S., Goldberg Y., Samara M., Davis J.M., Cipriani A., Leucht S. Initial severity of schizophrenia and efficacy of antipsychotics: participant-level meta-analysis of 6 placebo-controlled studies. JAMA Psychiatry. 2015;72(1):14–21. [http://dx.doi.org/10.1001/jamapsychiatry. 2014. 2127]. [PMID: 25372935]. - PubMed
    1. Goodkind M., Eickhoff S.B., Oathes D.J., Jiang Y., Chang A., Jones-Hagata L.B., Ortega B.N., Zaiko Y.V., Roach E.L., Korgaonkar M.S., Grieve S.M., Galatzer-Levy I., Fox P.T., Etkin A. Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry. 2015;72(4):305–315. [http://dx. doi.org/10.1001/jamapsychiatry.2014.2206]. [PMID: 25651064]. - PMC - PubMed

LinkOut - more resources