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. 2014 Fall;15(4):392-6.

The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration

Z Moradi  1 , S Azizi  2 , R Hobbenaghi  3
Affiliations

The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration

Z Moradi et al. Iran J Vet Res. 2014 Fall.

Abstract

A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P<0.05). Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group (P<0.05). Intraperitoneal administration of CoQ10 (10 mg/kg/day) in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration.

Keywords: Crush; Peripheral nerve regeneration; Ubiquinone (coenzyme Q10).

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Figures

Fig. 1
Fig. 1
Diagrammatic representation of effects on SFI. Intra peritoneal administration of CoQ10 (treatment group n=5) gave better results in the functional recovery of the sciatic nerve as compared to the un-treated animals (n=5). Data are presented as means ± SD. * P<0.05 vs. the un-treated group
Fig. 2
Fig. 2
Diagram of number of myelinated fibers in un-treated (n=5) and treatment (n=5) groups throughout the experiment
Fig. 3
Fig. 3
Photomicrograph of a cross-section of rat sciatic nerve (toluidine blue, ×400). A: Sham, the normal histologic appearance and size of axons in normal control group. B and C: 57 days after surgery, note different axon size in treatment and un-treated animals, respectively
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