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Editorial
. 2016 May 24;113(21):5766-7.
doi: 10.1073/pnas.1605618113. Epub 2016 May 13.

Food deprivation induces presynaptic plasticity in the autonomic nervous system

Ronald W Holz  1 , Arun Anantharam  2
Affiliations
Editorial

Food deprivation induces presynaptic plasticity in the autonomic nervous system

Ronald W Holz et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Plasticity in an autonomic synapse in the adrenal medulla helps maintain euglycemia and requires autocrine/paracrine modulation. Evidence is presented that mice maintain euglycemia during food deprivation because of increased secretion of epinephrine from the adrenal medulla. A component of the starvation-dependent increase of epinephrine secretion was an unexpected increase in the efficiency of splanchnic nerve synaptic transmission induced by an autocrine/paracrine feedback pathway at the splanchnic nerve/ chromaffin cell synapse. Wang et al. (4) provide evidence that the increase in release probability of cholinergic vesicles results from increased expression of NYP in chromaffin cells that, upon release, interacts with Y5-type NPY receptors on the splanchnic nerve terminal.
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