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Review
. 2016 Oct;21(5):349-55.
doi: 10.1016/j.siny.2016.04.009. Epub 2016 May 11.

Autism and cerebellar dysfunction: Evidence from animal models

Peter T Tsai  1
Affiliations
Review

Autism and cerebellar dysfunction: Evidence from animal models

Peter T Tsai. Semin Fetal Neonatal Med. 2016 Oct.

Abstract

Autism is a prevalent neurodevelopmental disorder whose origins are not well understood. Cerebellar involvement has been implicated in the pathogenesis of autism spectrum disorders with increasing evidence from both clinical studies and animal models supporting an important role for cerebellar dysfunction in autism spectrum disorders. This article discusses the various cerebellar contributions to autism spectrum disorders. Both clinical and preclinical studies are discussed and future research directions highlighted.

Keywords: Animal models; Autism spectrum disorders; Cerebellum; Circuitry; Critical periods.

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