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Review
. 2016 May 14;42(1):47.
doi: 10.1186/s13052-016-0260-9.

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

Victor Desmond Mandel  1 , Flavia Persechino  1 , Alberto Berardi  2 , Giovanni Ponti  3 , Silvana Ciardo  1 , Cecilia Rossi  4 , Giovanni Pellacani  1 , Francesca Farnetani  1
Affiliations
Review

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

Victor Desmond Mandel et al. Ital J Pediatr. .

Abstract

Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature.

Case presentation: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions.

Conclusion: We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.

Keywords: Chemotherapy; Congenital glioblastoma multiforme; Eruptive disseminated Spitz nevi; Reflectance confocal microscopy; Spitz nevi.

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Figures

Fig. 1
Fig. 1
Spitz nevus localized on the shoulder (a). Dermoscopy showed a starbust pattern with multiple pigmented striations and large brown globules distributed symmetrically at the periphery of the lesion (b). RCM revealed in the epidermis regular cobblestone with rare spindled (white arrow) and atypical cells (red arrow) (c). Instead at the dermoepidermal junction and within the papillary dermis showed the typical dense regular nests (yellow arrows). Moreover, papillary dermis presented edged papillae (green arrows) (d)
Fig. 2
Fig. 2
Spitz nevus localized on the trunk (a). Dermoscopy showed a globular pattern with regular, brownish central pigmentation and brownish globules at the periphery of the lesion (b). RCM revealed in the epidermis regular cobblestone with rare spindled (white arrow) and atypical cells (red arrow) (c). Instead at the dermoepidermal junction and within the papillary dermis showed the typical dense regular nests (yellow arrows). Moreover, papillary dermis presented edged papillae (green arrows) (d)
Fig. 3
Fig. 3
Spitz nevus localized on the back (a). Dermoscopy showed a multicomponent pattern with irregular pigmentation and a whitish-blue veil (b). RCM revealed in the epidermis irregular cobblestone with spindled (white arrows) and atypical cells (red arrows) (c). Instead at the dermoepidermal junction and within the papillary dermis showed nonedged papillae (green arrows) and plump bright cells (yellow arrows) (d)
See this image and copyright information in PMC

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