More trouble with FGF23: a novel role in systemic immunosuppression
- PMID: 27181769
- DOI: 10.1016/j.kint.2016.04.002
More trouble with FGF23: a novel role in systemic immunosuppression
Abstract
A recent study describes impaired neutrophil function as another adverse effect of the excessive levels of FGF23 found in the circulation of patients with chronic kidney disease. These findings shed light on the mechanisms by which chronic kidney disease leads to systemic immunosuppression.
Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment on
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FGF23 signaling impairs neutrophil recruitment and host defense during CKD.J Clin Invest. 2016 Mar 1;126(3):962-74. doi: 10.1172/JCI83470. Epub 2016 Feb 15. J Clin Invest. 2016. PMID: 26878171 Free PMC article.
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