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. 2016 Apr-Jun;7(2):90-4.
doi: 10.1016/j.jcot.2016.01.003. Epub 2016 Feb 4.

The effect of vitamin D and bisphosphonate on fracture healing: An experimental study

Nevres Hürriyet Aydoğan  1 , İrfan Özel  2 , Serkan İltar  3 , Talip Kara  3 , Ahmet Özmeriç  3 , Kadir Bahadır Alemdaroğlu  3
Affiliations

The effect of vitamin D and bisphosphonate on fracture healing: An experimental study

Nevres Hürriyet Aydoğan et al. J Clin Orthop Trauma. 2016 Apr-Jun.

Abstract

Background: The aim of the study was to evaluate the effects of the using bisphosphonate, vitamin D, and a combination of bisphosphonate and vitamin D on fracture healing, by comparison of radiological and histological findings of the study groups and a control group.

Methods: A total of 24 rats were randomly divided into 4 groups. A mid-third fracture was created in the femur of all rats. Saline was administered to Group A, bisphosphonate (Alendronate) to Group B, bisphosphonate (Alendronate) + vitamin D (Calcitriol) to Group C and vitamin D (Calcitriol) to Group D. All preparations were administered orally for 28 days.

Results: No statistically significant difference was determined between the groups in respect of the effect on fracture healing according to radiological findings. The histological findings of fracture healing showed Groups B and C to be significantly more advanced than Group A (p = 0.017, p = 0.009). However no significant difference was found in Group D comparison with Group A (p = 0.224).

Conclusion: According to the histological findings, advanced fracture healing was seen in the groups administered with bisphosphonate or combined bisphosphonate and vitamin D compared to the use of vitamin D alone and the control group. It was concluded that bisphosphonate treatment combined with vitamin D can be used safely without any negative effect on fracture healing.

Keywords: Bisphosphonates; Experimental study; Fracture healing; Osteoporosis; Vitamin D supplements.

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Figures

Fig. 1
Fig. 1
(a) The device used for fracturing of the rat femur is shown. (b) The middle 1/3 of femur rats were closed fracture through this device.
Fig. 2
Fig. 2
(a) Femoral condyles were revealed by surgical anteromedial longitudinal approach. (b) 0.8 mm Kirschner wire was placed through intercondylar notch.
Fig. 3
Fig. 3
(a) Kirschner wires for correcting the position by radiography was shown. (b) Fractures were corrected by radiography.
See this image and copyright information in PMC

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